Side Effects of Agomelatine (Valdoxan)
Agomelatine is an antidepressant used primarily to treat major depressive disorder (MDD). It works by influencing the melatonin receptors and serotonin levels, regulating sleep and mood. While generally well-tolerated, it can cause side effects.
Common Side Effects:
- Headache:
- Headaches are commonly reported when taking agomelatine, especially during the initial stages of treatment.
- Dizziness:
- Some individuals may experience dizziness or lightheadedness, particularly when adjusting to the medication.
- Nausea:
- Nausea and gastrointestinal discomfort, such as diarrhea or constipation, can occur, though they often subside over time.
- Fatigue:
- Tiredness or fatigue may be experienced, especially during the early phase of treatment.
- Sleep Disturbances:
- While agomelatine is prescribed to regulate sleep, some individuals may experience insomnia or vivid dreams.
- Increased Sweating:
- Night sweats or excessive sweating can occur as a side effect of agomelatine.
Serious Side Effects:
- Liver Toxicity:
- Agomelatine has been associated with liver problems. Regular liver function tests are recommended to monitor for signs of liver damage. Symptoms include yellowing of the skin or eyes (jaundice), dark urine, persistent fatigue, and upper abdominal pain.
- Mood Changes:
- Although it is used to treat depression, agomelatine may cause mood swings, irritability, or agitation in some individuals. In rare cases, it may increase suicidal thoughts or behavior, particularly in younger adults.
- Allergic Reactions:
- Severe allergic reactions to agomelatine are rare but possible. Symptoms may include rash, swelling of the face, lips, or throat, and difficulty breathing, which require immediate medical attention.
Who Should Avoid Agomelatine?
- Individuals with a history of liver disease or hepatic impairment should avoid agomelatine due to its potential impact on liver health.
- Pregnant or breastfeeding women should consult their healthcare provider before starting the medication, as safety data in these populations is limited.
Monitoring:
- Regular liver function tests are essential during treatment to catch early signs of liver damage.
- Regular check-ins with your healthcare provider to monitor mood changes or any unusual side effects.
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